Enrichment-triggered Prodrug Activation Demonstrated through Mitochondria-targeted Delivery of Doxorubicin and Carbon Monoxide

Controlled activation is a critical component in prodrug development. Herein we report a concentration-sensitive platform approach for bioorthogonal prodrug activation by taking advantage of reaction kinetics. Using two “click and release” systems, we demonstrate enrichment and prodrug activation sp...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Zheng, Yueqin, Ji, Xingyue, Yu, Bingchen, Ji, Kaili, Gallo, David, Csizmadia, Eva, Zhu, Mengyuan, Choudhury, Manjusha Roy, De La Cruz, Ladie Kimberly C., Chittavong, Vayou, Pan, Zhixiang, Yuan, Zhengnan, Otterbein, Leo E., Wang, Binghe
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235738/
https://ncbi.nlm.nih.gov/pubmed/29760413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-018-0055-2
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