Simultaneous administration of high-dose atorvastatin and clopidogrel does not interfere with platelet inhibition during percutaneous coronary intervention

BACKGROUND: Reloading with high-dose atorvastatin shortly before percutaneous coronary interventions (PCIs) has been proposed as a strategy to reduce periprocedural myonecrosis. There has been a concern that statins that are metabolized by cytochrome P450 3A4 may interfere with clopidogrel metabolis...

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Publicat a:Clin Pharmacol
Autors principals: Kreutz, Rolf P, Breall, Jeffrey A, Sinha, Anjan, von der Lohe, Elisabeth, Kovacs, Richard J, Flockhart, David A
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4902146/
https://ncbi.nlm.nih.gov/pubmed/27350760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CPAA.S98790
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