Enhanced Muscular Dystrophy from Loss of Dysferlin Is Accompanied by Impaired Annexin A6 Translocation after Sarcolemmal Disruption

Dysferlin is a membrane-associated protein implicated in membrane resealing; loss of dysferlin leads to muscular dystrophy. We examined the same loss-of-function Dysf mutation in two different mouse strains, 129T2/SvEmsJ (Dysf(129)) and C57BL/6J (Dysf(B6)). Although there are many genetic difference...

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Udgivet i:Am J Pathol
Main Authors: Demonbreun, Alexis R., Allen, Madison V., Warner, James L., Barefield, David Y., Krishnan, Swathi, Swanson, Kaitlin E., Earley, Judy U., McNally, Elizabeth M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901136/
https://ncbi.nlm.nih.gov/pubmed/27070822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.02.005
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