Population Pharmacokinetics of Unbound and Total Drug Concentrations Following Intravenously Administered Carbamazepine in Elderly and Younger Adult Patients With Epilepsy

The objective of the study was to investigate the pharmacokinetics (PK) of unbound and total plasma carbamazepine (CBZ) concentrations following simultaneous administration of intravenous and oral formulations. We tested the hypothesis that age-related alterations in physiology and patient character...

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Publicat a:J Clin Pharmacol
Autors principals: Ahmed, Ghada F., Brundage, Richard C., Marino, Susan E., Cloyd, James C., Leppik, Ilo E., Pennell, Page B., Ramsay, R. Eugene, Birnbaum, Angela K.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900893/
https://ncbi.nlm.nih.gov/pubmed/23408495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.8
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