Pharmacokinetic–pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers

AIMS: The aim was to develop a quantitative approach that characterizes the magnitude of and variability in phonemic generative fluency scores as measured by the Controlled Oral Word Association (COWA) test in healthy volunteers after administration of an oral and a novel intravenous (IV) formulatio...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Ahmed, Ghada F, Marino, Susan E, Brundage, Richard C, Pakhomov, Serguei V S, Leppik, Ilo E, Cloyd, James C, Clark, Annie, Birnbaum, Angela K
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Pharmacokinetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4415718/
https://ncbi.nlm.nih.gov/pubmed/25403343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12556
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