A single infusion of MDCO-216 (ApoA-1 Milano/POPC) increases ABCA1-mediated cholesterol efflux and pre-beta 1 HDL in healthy volunteers and patients with stable coronary artery disease

AIMS: Apolipoprotein A-1 (ApoA-1), based on epidemiology, is inversely associated with cardiovascular (CV) events. Human carriers of the ApoA-1 Milano variant have a reduced incidence of CV disease. Regression of atherosclerotic plaque burden was previously observed on intravascular ultrasound (IVUS...

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Publicat a:Eur Heart J Cardiovasc Pharmacother
Autors principals: Kallend, D.G., Reijers, J.A.A., Bellibas, S.E., Bobillier, A., Kempen, H., Burggraaf, J., Moerland, M., Wijngaard, P.L.J.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900740/
https://ncbi.nlm.nih.gov/pubmed/27418968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ehjcvp/pvv041
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