Effect of repeated apoA-IMilano/POPC infusion on lipids, (apo)lipoproteins, and serum cholesterol efflux capacity in cynomolgus monkeys

MDCO-216, a complex of dimeric recombinant apoA-IMilano (apoA-IM) and palmitoyl-oleoyl-phosphatidylcholine (POPC), was administered to cynomolgus monkeys at 30, 100, and 300 mg/kg every other day for a total of 21 infusions, and effects on lipids, (apo)lipoproteins, and ex-vivo cholesterol efflux ca...

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Autores principales: Kempen, Herman J., Gomaraschi, Monica, Bellibas, S. Eralp, Plassmann, Stephanie, Zerler, Brad, Collins, Heidi L., Adelman, Steven J., Calabresi, Laura, Wijngaard, Peter L. J.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2013
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735933/
https://ncbi.nlm.nih.gov/pubmed/23828780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M033779
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