Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

Human CD4 T cells are constantly exposed to IL-12 during infections and certain autoimmune disorders. The current paradigm is that IL-12 promotes the differentiation of naïve CD4 T cells into Th1 cells, but recent studies suggest IL-12 may play a more complex role in T cell biology. We examined if e...

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Udgivet i:PLoS One
Main Authors: Vacaflores, Aldo, Chapman, Nicole M., Harty, John T., Richer, Martin J., Houtman, Jon C. D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900534/
https://ncbi.nlm.nih.gov/pubmed/27280403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157175
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