Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called ferroptosis. To study the relevance of Gpx4 and of another vitally importan...

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Detalles Bibliográficos
Publicado en:Redox Biol
Main Authors: Carlson, Bradley A., Tobe, Ryuta, Yefremova, Elena, Tsuji, Petra A., Hoffmann, Victoria J., Schweizer, Ulrich, Gladyshev, Vadim N., Hatfield, Dolph L., Conrad, Marcus
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900515/
https://ncbi.nlm.nih.gov/pubmed/27262435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.05.003
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