Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

Numerous studies characterizing the function of glutathione peroxidase 4 (GPx4) have demonstrated that this selenoenzyme is protective against oxidative stress. Herein, we characterized the function of this protein by targeting GPx4 downregulation using RNA interference. Partial knockdown of GPx4 le...

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Detalhes bibliográficos
Main Authors: Yoo, Min-Hyuk, Gu, Xinglong, Xu, Xue-Ming, Kim, Jin-Young, Carlson, Bradley A., Patterson, Andrew D., Cai, Huaibin, Gladyshev, Vadim N., Hatfield, Dolph L.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Forum Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861544/
https://ncbi.nlm.nih.gov/pubmed/19769463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2009.2891
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