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Sleeping Beauty transposon insertional mutagenesis based mouse models for cancer gene discovery

Large-scale genomic efforts to study human cancer, such as the cancer gene atlas (TCGA), have identified numerous cancer drivers in a wide variety of tumor types. However, there are limitations to this approach, the mutations and expression or copy number changes that are identified are not always c...

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Bibliographic Details
Published in:Curr Opin Genet Dev
Main Authors: Moriarity, Branden S, Largaespada, David A
Format: Artigo
Language:Inglês
Published: 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4900178/
https://ncbi.nlm.nih.gov/pubmed/26051241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2015.04.007
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