Absence of a reductase, NCB5OR, causes insulin-deficient diabetes

NCB5OR is a highly conserved NAD(P)H reductase that contains a cytochrome b5-like domain at the N terminus and a cytochrome b5 reductase-like domain at the C terminus. The enzyme is located in the endoplasmic reticulum (ER) and is widely expressed in organs and tissues. Targeted inactivation of this...

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Autori principali: Xie, Jianxin, Zhu, Hao, Larade, Kevin, Ladoux, Annie, Seguritan, Ayden, Chu, Michelle, Ito, Susumu, Bronson, Roderick T., Leiter, Edward H., Zhang, Chen-Yu, Rosen, Evan D., Bunn, H. Franklin
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC490006/
https://ncbi.nlm.nih.gov/pubmed/15247412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404044101
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