Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E

Toll-like receptors (TLRs) and the downstream adaptor molecule myeloid differentiation factor 88 (MyD88) play an essential role in the innate immune responses. Here, we demonstrate that genetic deficiency of TLR4 or MyD88 is associated with a significant reduction of aortic plaque areas in atheroscl...

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Detalhes bibliográficos
Main Authors: Michelsen, Kathrin S., Wong, Michelle H., Shah, Prediman K., Zhang, Wenxuan, Yano, Juliana, Doherty, Terence M., Akira, Shizuo, Rajavashisth, Tripathi B., Arditi, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC489994/
https://ncbi.nlm.nih.gov/pubmed/15249654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403249101
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