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Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors

We have determined the crystal structure of the HIV type 1 reverse transcriptase complexed with CP-94,707, a new nonnucleoside reverse transcriptase inhibitor (NNRTI), to 2.8-Å resolution. In addition to inhibiting the wild-type enzyme, this compound inhibits mutant enzymes that are resistant to inh...

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Autori principali: Pata, Janice D., Stirtan, William G., Goldstein, Steven W., Steitz, Thomas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC489975/
https://ncbi.nlm.nih.gov/pubmed/15249669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404151101
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