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Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors

We have determined the crystal structure of the HIV type 1 reverse transcriptase complexed with CP-94,707, a new nonnucleoside reverse transcriptase inhibitor (NNRTI), to 2.8-Å resolution. In addition to inhibiting the wild-type enzyme, this compound inhibits mutant enzymes that are resistant to inh...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Pata, Janice D., Stirtan, William G., Goldstein, Steven W., Steitz, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC489975/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15249669/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404151101
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