Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer’s disease: metabolic basis for dementia

Impairment of brain-glucose uptake and brain-copper regulation occurs in Alzheimer’s disease (AD). Here we sought to further elucidate the processes that cause neurodegeneration in AD by measuring levels of metabolites and metals in brain regions that undergo different degrees of damage. We employed...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Xu, Jingshu, Begley, Paul, Church, Stephanie J., Patassini, Stefano, McHarg, Selina, Kureishy, Nina, Hollywood, Katherine A., Waldvogel, Henry J., Liu, Hong, Zhang, Shaoping, Lin, Wanchang, Herholz, Karl, Turner, Clinton, Synek, Beth J., Curtis, Maurice A., Rivers-Auty, Jack, Lawrence, Catherine B., Kellett, Katherine A. B., Hooper, Nigel M., Vardy, Emma R. L. C., Wu, Donghai, Unwin, Richard D., Faull, Richard L. M., Dowsey, Andrew W., Cooper, Garth J. S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2016
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899713/
https://ncbi.nlm.nih.gov/pubmed/27276998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27524
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia