Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer’s disease: metabolic basis for dementia

Impairment of brain-glucose uptake and brain-copper regulation occurs in Alzheimer’s disease (AD). Here we sought to further elucidate the processes that cause neurodegeneration in AD by measuring levels of metabolites and metals in brain regions that undergo different degrees of damage. We employed...

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Publicat a:Sci Rep
Autors principals: Xu, Jingshu, Begley, Paul, Church, Stephanie J., Patassini, Stefano, McHarg, Selina, Kureishy, Nina, Hollywood, Katherine A., Waldvogel, Henry J., Liu, Hong, Zhang, Shaoping, Lin, Wanchang, Herholz, Karl, Turner, Clinton, Synek, Beth J., Curtis, Maurice A., Rivers-Auty, Jack, Lawrence, Catherine B., Kellett, Katherine A. B., Hooper, Nigel M., Vardy, Emma R. L. C., Wu, Donghai, Unwin, Richard D., Faull, Richard L. M., Dowsey, Andrew W., Cooper, Garth J. S.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899713/
https://ncbi.nlm.nih.gov/pubmed/27276998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27524
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