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Directed evolution of ligand dependence: Small-molecule-activated protein splicing
Artificial molecular switches that modulate protein activities in response to synthetic small molecules would serve as tools for exerting temporal and dose-dependent control over protein function. Self-splicing protein elements (inteins) are attractive starting points for the creation of such switch...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC489967/ https://ncbi.nlm.nih.gov/pubmed/15247421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402762101 |
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