Laddar...
Creation and discovery of ligand–receptor pairs for transcriptional control with small molecules
The nuclear receptor retinoid X receptor (RXR) is a ligand-activated transcription factor. To create receptors for a new ligand, a structure-based approach was used to generate a library of ≈380,000 mutant RXR genes. To discover functional variants within the library, we used chemical complementatio...
Sparad:
| Huvudupphovsmän: | , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2004
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522017/ https://ncbi.nlm.nih.gov/pubmed/15456909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400884101 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|