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Creation and discovery of ligand–receptor pairs for transcriptional control with small molecules
The nuclear receptor retinoid X receptor (RXR) is a ligand-activated transcription factor. To create receptors for a new ligand, a structure-based approach was used to generate a library of ≈380,000 mutant RXR genes. To discover functional variants within the library, we used chemical complementatio...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC522017/ https://ncbi.nlm.nih.gov/pubmed/15456909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400884101 |
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