Oligomerization of the Microtubule Associated Protein Tau is Mediated by its N-Terminal Sequences: Implications for Normal and Pathological Tau Action

Despite extensive structure-function analyses, the molecular mechanisms of normal and pathological tau action remain poorly understood. How does the C-terminal microtubule-binding region regulate microtubule dynamics and bundling? In what biophysical form does tau transfer trans-synaptically from on...

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Bibliografske podrobnosti
izdano v:J Neurochem
Main Authors: Feinstein, H. Eric, Benbow, Sarah J., LaPointe, Nichole E., Patel, Nirav, Ramachandran, Srinivasan, Do, Thanh D., Gaylord, Michelle R., Huskey, Noelle E., Dressler, Nicolette, Korff, Megan, Quon, Brady, Cantrell, Kristi Lazar, Bowers, Michael T., Lal, Ratnesh, Feinstein, Stuart C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899250/
https://ncbi.nlm.nih.gov/pubmed/26953146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13604
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