Smad7 Interrupts TGF-β Signaling in Intestinal Macrophages and Promotes Inflammatory Activation of these Cells during Necrotizing Enterocolitis

BACKGROUND: Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants. Based on our recent findings of increased Smad7 expression in surgically-resected bowel affected by NEC, we hypothesized that NEC macrophages undergo inflammatory activation because increased Smad7 ex...

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Pubblicato in:Pediatr Res
Autori principali: MohanKumar, Krishnan, Namachivayam, Kopperuncholan, Chapalamadugu, Kalyan, Garzon, Steven A., Premkumar, Muralidhar H., Tipparaju, Srinivas, Maheshwari, Akhil
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4899224/
https://ncbi.nlm.nih.gov/pubmed/26859364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2016.18
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