Targeted inhibition of thrombin attenuates murine neonatal necrotizing enterocolitis

Necrotizing enterocolitis (NEC) is an inflammatory bowel necrosis of premature infants and an orphan disease with no specific treatment. Most patients with confirmed NEC develop moderate-severe thrombocytopenia requiring one or more platelet transfusions. Here we used our neonatal murine model of NE...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Namachivayam, Kopperuncholan, MohanKumar, Krishnan, Shores, Darla R., Jain, Sunil K., Fundora, Jennifer, Everett, Allen D., He, Ling, Pan, Hua, Wickline, Samuel A., Maheshwari, Akhil
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7245134/
https://ncbi.nlm.nih.gov/pubmed/32366656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912357117
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