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Lack of mGluR6-Related Cascade Elements leads to Retrograde Trans-synaptic Effects on Rod Photoreceptor Synapses via Matrix-associated Proteins
Heterotrimeric G-proteins couple metabotropic receptors to downstream effectors. In retinal ON bipolar cells, G(o) couples the metabotropic receptor mGluR6 to the TRPM1 channel and closes it in the dark, thus hyperpolarizing the cell. Light, via GTPase activating proteins, deactivates G(o), opens TR...
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| Publicado no: | Eur J Neurosci |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4899192/ https://ncbi.nlm.nih.gov/pubmed/27037829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.13243 |
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