TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy

Haplodeficiency of the microglia gene TREM2 increases risk for late-onset Alzheimer’s disease (AD) but the mechanisms remain uncertain. To investigate this, we used high-resolution confocal and super-resolution (STORM) microscopy in AD-like mice and human AD tissue. We found that microglia processes...

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Publicat a:Neuron
Autors principals: Yuan, Peng, Condello, Carlo, Keene, C. Dirk, Wang, Yaming, Bird, Thomas D., Paul, Steven M., Luo, Wenjie, Colonna, Marco, Baddeley, David, Grutzendler, Jaime
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898967/
https://ncbi.nlm.nih.gov/pubmed/27196974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.05.003
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