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The Somatic Nature of Cancer Allows It to Affect Highly Constrained Genes

Cancer is special among genetic disorders in two major ways: first, cancer is a disease of the most basic of cellular functions, such as cell proliferation, differentiation, and the maintenance of genomic integrity. Second, in contrast to most genetic disorders that are mediated by germline (heredit...

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Detalhes bibliográficos
Publicado no:Genome Biol Evol
Main Authors: Ostrow, Sheli L., Hershberg, Ruth
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898816/
https://ncbi.nlm.nih.gov/pubmed/27190005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evw110
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