Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection

Different tumor types vary greatly in their distribution of driver substitutions. Here, we analyzed how mutation and natural selection contribute to differences in the distribution of KRAS driver substitutions between lung, colon and pancreatic adenocarcinomas. We were able to demonstrate that both...

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Vydáno v:Sci Rep
Hlavní autoři: Ostrow, Sheli L., Simon, Einav, Prinz, Elad, Bick, Tova, Shentzer, Talia, Nagawkar, Sima S., Sabo, Edmond, Ben-Izhak, Ofer, Hershberg, Ruth, Hershkovitz, Dov
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763303/
https://ncbi.nlm.nih.gov/pubmed/26902163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21927
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