Variation in KRAS driver substitution distributions between tumor types is determined by both mutation and natural selection

Different tumor types vary greatly in their distribution of driver substitutions. Here, we analyzed how mutation and natural selection contribute to differences in the distribution of KRAS driver substitutions between lung, colon and pancreatic adenocarcinomas. We were able to demonstrate that both...

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מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Ostrow, Sheli L., Simon, Einav, Prinz, Elad, Bick, Tova, Shentzer, Talia, Nagawkar, Sima S., Sabo, Edmond, Ben-Izhak, Ofer, Hershberg, Ruth, Hershkovitz, Dov
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2016
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763303/
https://ncbi.nlm.nih.gov/pubmed/26902163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep21927
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