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Direct CRISPR spacer acquisition from RNA by a natural reverse-transcriptase-Cas1 fusion protein
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) systems mediate adaptive immunity in diverse prokaryotes. CRISPR-associated Cas1 and Cas2 proteins have been shown to enable adaptation to new threats in Type I and II CRISPR systems by the acquisition of short segments of DNA (“space...
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| Publié dans: | Science |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4898656/ https://ncbi.nlm.nih.gov/pubmed/26917774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad4234 |
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