Direct CRISPR spacer acquisition from RNA by a natural reverse-transcriptase-Cas1 fusion protein

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) systems mediate adaptive immunity in diverse prokaryotes. CRISPR-associated Cas1 and Cas2 proteins have been shown to enable adaptation to new threats in Type I and II CRISPR systems by the acquisition of short segments of DNA (“space...

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Foilsithe in:Science
Main Authors: Silas, Sukrit, Mohr, Georg, Sidote, David J., Markham, Laura M., Sanchez-Amat, Antonio, Bhaya, Devaki, Lambowitz, Alan M., Fire, Andrew Z.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898656/
https://ncbi.nlm.nih.gov/pubmed/26917774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad4234
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