Myeloid cells in peripheral blood mononuclear cell concentrates inhibit the expansion of chimeric antigen receptor T cells

BACKGROUND AIMS: Autologous chimeric antigen receptor (CAR) T-cell therapies have shown promising clinical outcomes, but T-cell yields have been variable. CD19- and GD2-CAR T-cell manufacturing records were reviewed to identify sources of variability. METHODS: CD19-CAR T cells were used to treat 43...

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Vydáno v:Cytotherapy
Hlavní autoři: STRONCEK, DAVID F., REN, JIAQIANG, LEE, DANIEL W., TRAN, MINH, FRODIGH, SUE ELLEN, SABATINO, MARIANNA, KHUU, HANH, MERCHANT, MELINDA S., MACKALL, CRYSTAL L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4898642/
https://ncbi.nlm.nih.gov/pubmed/27210719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2016.04.003
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