PolyMetformin combines carrier and anticancer activities for in vivo siRNA delivery

Metformin, a widely implemented anti-diabetic drug, exhibits potent anticancer efficacies. Herein a polymeric construction of Metformin, PolyMetformin (PolyMet) is successfully synthesized through conjugation of linear polyethylenimine (PEI) with dicyandiamide. The delocalization of cationic charges...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Zhao, Yi, Wang, Wei, Guo, Shutao, Wang, Yuhua, Miao, Lei, Xiong, Yang, Huang, Leaf
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897747/
https://ncbi.nlm.nih.gov/pubmed/27264609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11822
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