Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia

Fusion genes are potent driver mutations in cancer. In this study, we delineate the fusion gene landscape in a consecutive series of 195 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP ALL). Using RNA sequencing, we find in-frame fusion genes in 127 (65%) cases, including 27 novel fus...

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發表在:Nat Commun
Main Authors: Lilljebjörn, Henrik, Henningsson, Rasmus, Hyrenius-Wittsten, Axel, Olsson, Linda, Orsmark-Pietras, Christina, von Palffy, Sofia, Askmyr, Maria, Rissler, Marianne, Schrappe, Martin, Cario, Gunnar, Castor, Anders, Pronk, Cornelis J. H., Behrendtz, Mikael, Mitelman, Felix, Johansson, Bertil, Paulsson, Kajsa, Andersson, Anna K., Fontes, Magnus, Fioretos, Thoas
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897744/
https://ncbi.nlm.nih.gov/pubmed/27265895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11790
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