Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity

A detailed characterisation of the molecular determinants of membrane binding by α-synuclein (αS), a 140-residue protein whose aggregation is associated with Parkinson’s disease, is of fundamental significance to clarify the manner in which the balance between functional and dysfunctional processes...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Fusco, Giuliana, De Simone, Alfonso, Arosio, Paolo, Vendruscolo, Michele, Veglia, Gianluigi, Dobson, Christopher M.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897633/
https://ncbi.nlm.nih.gov/pubmed/27273030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27125
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