Modulation of oxidative stress and subsequent induction of apoptosis and endoplasmic reticulum stress allows citral to decrease cancer cell proliferation

The monoterpenoid, citral, when delivered through PEG-b-PCL nanoparticles inhibits in vivo growth of 4T1 breast tumors. Here, we show that citral inhibits proliferation of multiple human cancer cell lines. In p53 expressing ECC-1 and OVCAR-3 but not in p53-deficient SKOV-3 cells, citral induces G1/S...

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Publicado en:Sci Rep
Autores principales: Kapur, Arvinder, Felder, Mildred, Fass, Lucas, Kaur, Justanjot, Czarnecki, Austin, Rathi, Kavya, Zeng, San, Osowski, Kathryn Kalady, Howell, Colin, Xiong, May P., Whelan, Rebecca J., Patankar, Manish S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897611/
https://ncbi.nlm.nih.gov/pubmed/27270209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27530
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