Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing

Differentiated somatic cells can be reprogrammed into totipotent embryos through somatic cell nuclear transfer. However, most cloned embryos arrest at early stages and the underlying molecular mechanism remains largely unexplored. Here, we first developed a somatic cell nuclear transfer embryo biops...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Discov
Prif Awduron: Liu, Wenqiang, Liu, Xiaoyu, Wang, Chenfei, Gao, Yawei, Gao, Rui, Kou, Xiaochen, Zhao, Yanhong, Li, Jingyi, Wu, You, Xiu, Wenchao, Wang, Su, Yin, Jiqing, Liu, Wei, Cai, Tao, Wang, Hong, Zhang, Yong, Gao, Shaorong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897595/
https://ncbi.nlm.nih.gov/pubmed/27462457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.10
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