Identification of key factors conquering developmental arrest of somatic cell cloned embryos by combining embryo biopsy and single-cell sequencing

Differentiated somatic cells can be reprogrammed into totipotent embryos through somatic cell nuclear transfer. However, most cloned embryos arrest at early stages and the underlying molecular mechanism remains largely unexplored. Here, we first developed a somatic cell nuclear transfer embryo biops...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Liu, Wenqiang, Liu, Xiaoyu, Wang, Chenfei, Gao, Yawei, Gao, Rui, Kou, Xiaochen, Zhao, Yanhong, Li, Jingyi, Wu, You, Xiu, Wenchao, Wang, Su, Yin, Jiqing, Liu, Wei, Cai, Tao, Wang, Hong, Zhang, Yong, Gao, Shaorong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4897595/
https://ncbi.nlm.nih.gov/pubmed/27462457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2016.10
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