Suicide gene approach using a dual-expression lentiviral vector to enhance the safety of ex vivo gene therapy for bone repair

‘Ex vivo’ gene therapy using viral vectors to overexpress BMP-2 is shown to heal critical-sized bone defects in experimental animals. To increase its safety, we constructed a dual-expression lentiviral vector to overexpress BMP-2 or luciferase and an HSV1-tk analog, Δtk (LV-Δtk-T2A-BMP-2/Luc). We hy...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Gene Ther
Main Authors: Alaee, F, Sugiyama, O, Virk, MS, Tang, H, Drissi, H, Lichtler, AC, Lieberman, JR
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896754/
https://ncbi.nlm.nih.gov/pubmed/24285218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2013.66
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker