S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3

Lysine to methionine (K-to-M) mutations in genes encoding histone H3 are thought to drive a subset of pediatric brain and bone cancers. These high-frequency K-to-M mutations occur at sites of methylation on histone H3, and tumors containing the mutant histones exhibit a global loss of specific histo...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jayaram, Hariharan, Hoelper, Dominik, Jain, Siddhant U., Cantone, Nico, Lundgren, Stefan M., Poy, Florence, Allis, C. David, Cummings, Richard, Bellon, Steven, Lewis, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896705/
https://ncbi.nlm.nih.gov/pubmed/27185940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605523113
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