Immunotherapy of tuberculosis with Mycobacterium leprae Hsp65 as a DNA vaccine triggers cross-reactive antibodies against mammalian Hsp60 but not pathological autoimmunity

Despite substantial efforts in recent years toward the development of new vaccines and drugs against tuberculosis (TB), success has remained elusive. Immunotherapy of TB with mycobacterial Hsp65 as a DNA vaccine (DNA-hsp65) results in a reduction of systemic bacterial loads and lung tissue damage, b...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Doimo, Nayara TS, Zárate-Bladés, Carlos R, Rodrigues, Rodrigo F, Tefé-Silva, Cristiane, Trotte, Marcele NS, Souza, Patrícia RM, Soares, Luana S, Rios, Wendy M, Floriano, Elaine M, Brandão, Izaira T, Masson, Ana P, Coelho, Verônica, Ramos, Simone G, Silva, Celio L
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896578/
https://ncbi.nlm.nih.gov/pubmed/24607935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.28249
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