Immunotherapy of tuberculosis with Mycobacterium leprae Hsp65 as a DNA vaccine triggers cross-reactive antibodies against mammalian Hsp60 but not pathological autoimmunity

Despite substantial efforts in recent years toward the development of new vaccines and drugs against tuberculosis (TB), success has remained elusive. Immunotherapy of TB with mycobacterial Hsp65 as a DNA vaccine (DNA-hsp65) results in a reduction of systemic bacterial loads and lung tissue damage, b...

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Vydáno v:Hum Vaccin Immunother
Hlavní autoři: Doimo, Nayara TS, Zárate-Bladés, Carlos R, Rodrigues, Rodrigo F, Tefé-Silva, Cristiane, Trotte, Marcele NS, Souza, Patrícia RM, Soares, Luana S, Rios, Wendy M, Floriano, Elaine M, Brandão, Izaira T, Masson, Ana P, Coelho, Verônica, Ramos, Simone G, Silva, Celio L
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2014
Témata:
Short Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4896578/
https://ncbi.nlm.nih.gov/pubmed/24607935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/hv.28249
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