Combined immunization using DNA-Sm14 and DNA-Hsp65 increases CD8+ memory T cells, reduces chronic pathology and decreases egg viability during Schistosoma mansoni infection

BACKGROUND: Schistosomiasis is one of the most important neglected diseases found in developing countries and affects 249 million people worldwide. The development of an efficient vaccination strategy is essential for the control of this disease. Previous work showed partial protection induced by DN...

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Main Authors: Espíndola, Milena Sobral, Frantz, Fabiani Gai, Soares, Luana Silva, Masson, Ana Paula, Tefé-Silva, Cristiane, Bitencourt, Claudia Silva, Oliveira, Sérgio Costa, Rodrigues, Vanderlei, Ramos, Simone Gusmão, Silva, Célio Lopes, Faccioli, Lúcia Helena
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031977/
https://ncbi.nlm.nih.gov/pubmed/24886395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-14-263
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