Inhibition of poly(adenosine diphosphate-ribose) polymerase attenuates ventilator-induced lung injury

BACKGROUND: Mechanical ventilation can induce organ injury associated with overwhelming inflammatory responses. Excessive activation of poly(adenosine diphosphate-ribose) polymerase enzyme following massive DNA damage may aggravate inflammatory responses. We thus hypothesized that the pharmacologica...

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Gepubliceerd in:Anesthesiology
Hoofdauteurs: Vaschetto, Rosanna, Kuiper, Jan W., Chiang, Johnson, Haitsma, Jack J., Juco, Jonathan W., Uhlig, Stefan, Plötz, Frans B., Della Corte, Francesco, Zhang, Haibo, Slutsky, Arthur S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894820/
https://ncbi.nlm.nih.gov/pubmed/18212571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/01.anes.0000299434.86640.15
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