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Poly(Adenosine Diphosphate–Ribose) Polymerase Inhibitors in Cancer Treatment
Recently, the development of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors has brought a major breakthrough in the treatment of germline breast cancer susceptibility gene (BRCA)-mutant cancers.(1-4) These agents target a DNA repair pathway via a novel mechanism of action. A b...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3600582/ https://ncbi.nlm.nih.gov/pubmed/22520984 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hoc.2012.02.012 |
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