Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

Formation of a regularly branched blood vessel network is crucial in development and physiology. Here we show that the expression of the Notch ligand Dll4 fluctuates in individual endothelial cells within sprouting vessels in the mouse retina in vivo and in correlation with dynamic cell movement in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Ubezio, Benedetta, Blanco, Raquel Agudo, Geudens, Ilse, Stanchi, Fabio, Mathivet, Thomas, Jones, Martin L, Ragab, Anan, Bentley, Katie, Gerhardt, Holger
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2016
Pynciau:
Computational and Systems Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894757/
https://ncbi.nlm.nih.gov/pubmed/27074663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12167
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