Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation

DNA 5-methylcytosine is a dynamic epigenetic mark which plays important roles in development and disease. In the Tet-Tdg demethylation pathway, methylated cytosine is iteratively oxidized by Tet dioxygenases and unmodified cytosine is restored via thymine DNA glycosylase (Tdg). Here we show that hum...

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Detaylı Bibliyografya
Yayımlandı:Nat Struct Mol Biol
Asıl Yazarlar: Schomacher, Lars, Han, Dandan, Musheev, Michael U., Arab, Khelifa, Kienhöfer, Sabine, von Seggern, Annika, Niehrs, Christof
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2016
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894546/
https://ncbi.nlm.nih.gov/pubmed/26751644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3151
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