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Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation
DNA 5-methylcytosine is a dynamic epigenetic mark which plays important roles in development and disease. In the Tet-Tdg demethylation pathway, methylated cytosine is iteratively oxidized by Tet dioxygenases and unmodified cytosine is restored via thymine DNA glycosylase (Tdg). Here we show that hum...
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| Publié dans: | Nat Struct Mol Biol |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4894546/ https://ncbi.nlm.nih.gov/pubmed/26751644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3151 |
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