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Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG

Two mammalian DNA glycosylases, methyl-CpG binding domain protein 4 (MBD4) and thymine DNA glycosylase (TDG), are involved in active DNA demethylation via the base excision repair pathway. Both MBD4 and TDG excise the mismatch base from G:X, where X is uracil, thymine, and 5-hydroxymethyluracil (5hm...

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Detalhes bibliográficos
Publicado no:Biophysics (Nagoya-shi)
Autor principal: Hashimoto, Hideharu
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society of Japan (BSJ) 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4629659/
https://ncbi.nlm.nih.gov/pubmed/27493500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2142/biophysics.10.63
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