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No Evidence for AID/MBD4-Coupled DNA Demethylation in Zebrafish Embryos

The mechanisms responsible for active DNA demethylation remain elusive in Metazoa. A previous study that utilized zebrafish embryos provided a potent mechanism for active demethylation in which three proteins, AID, MBD4, and GADD45 are involved. We recently found age-dependent DNA hypomethylation in...

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Pubblicato in:PLoS One
Autori principali: Shimoda, Nobuyoshi, Hirose, Kentaro, Kaneto, Reiya, Izawa, Toshiaki, Yokoi, Hayato, Hashimoto, Naohiro, Kikuchi, Yutaka
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275248/
https://ncbi.nlm.nih.gov/pubmed/25536520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0114816
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