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Structural and mutation studies of two DNA demethylation related glycosylases: MBD4 and TDG
Two mammalian DNA glycosylases, methyl-CpG binding domain protein 4 (MBD4) and thymine DNA glycosylase (TDG), are involved in active DNA demethylation via the base excision repair pathway. Both MBD4 and TDG excise the mismatch base from G:X, where X is uracil, thymine, and 5-hydroxymethyluracil (5hm...
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| Опубликовано в: : | Biophysics (Nagoya-shi) |
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| Главный автор: | |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Biophysical Society of Japan (BSJ)
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4629659/ https://ncbi.nlm.nih.gov/pubmed/27493500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2142/biophysics.10.63 |
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