Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial

AIMS/HYPOTHESIS: The molecular mechanisms by which thiazolidinediones improve insulin sensitivity in type 2 diabetes are not fully understood. We hypothesised that pioglitazone would activate the adenosine 5′-monophosphate-activated protein kinase (AMPK) pathway and increase the expression of genes...

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Udgivet i:Diabetologia
Main Authors: Coletta, D. K., Sriwijitkamol, A., Wajcberg, E., Tantiwong, P., Li, M., Prentki, M., Madiraju, M., Jenkinson, C. P., Cersosimo, E., Musi, N., DeFronzo, R. A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4894502/
https://ncbi.nlm.nih.gov/pubmed/19169664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-008-1256-9
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