Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

OBJECTIVE— Tall-like receptor (TLR)4 has been implicated in the pathogenesis of free fatty acid (FFA)-induced insulin resistance by activating inflammatory pathways, including inhibitor of κB (IκB)/nuclear factor κB (NFκB). However, it is not known whether insulin-resistant subjects have abnormal TL...

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Bibliographic Details
Main Authors: Reyna, Sara M., Ghosh, Sangeeta, Tantiwong, Puntip, Meka, C.S. Reddy, Eagan, Phyllis, Jenkinson, Christopher P., Cersosimo, Eugenio, DeFronzo, Ralph A., Coletta, Dawn K., Sriwijitkamol, Apiradee, Musi, Nicolas
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2008
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2551667/
https://ncbi.nlm.nih.gov/pubmed/18633101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-0038
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