Effect of a sustained reduction in plasma free fatty acid concentration on insulin signalling and inflammation in skeletal muscle from human subjects

Free fatty acids (FFAs) have been implicated in the pathogenesis of insulin resistance. Reducing plasma FFA concentration in obese and type 2 diabetic (T2DM) subjects improves insulin sensitivity. However, the molecular mechanism by which FFA reduction improves insulin sensitivity in human subjects...

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Main Authors: Liang, Hanyu, Tantiwong, Puntip, Sriwijitkamol, Apiradee, Shanmugasundaram, Karthigayan, Mohan, Sumathy, Espinoza, Sara, DeFronzo, Ralph A, Dubé, John J, Musi, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2013
Assuntos:
Skeletal Muscle and Exercise
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690693/
https://ncbi.nlm.nih.gov/pubmed/23529132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.247510
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